By Andrea Park CBS News November 21, 2018, 11:41 AM Robert De Niro and Grace Hightower reportedly call it quits after 21 years of marriage

US actor Robert de Niro and his wife Grace Hightower arrive on May 16, 2016 for the screening of the film "Hands of Stone" at the 69th Cannes Film Festival in Cannes, southern France.

Alberto Pizzoli/AFP/Getty Images

Longtime couple Robert De Niro and Grace Hightower have reportedly called it quits after 21 years of marriage. ET reports that the outspoken actor and his philanthropist wife have split.

De Niro and Hightower have broken up before. The couple, who met in 1987, married in 1997. They split in 1999 but reconciled, and never finalized their divorce. In 2004, they renewed their vows.

The couple share two children: son Elliot, born in 1998, and daughter Helen Grace, born in 2011.

In 2013, De Niro talked to CBS News about his family and his daughter, who was just 1 at the time.

"She's so adorable. You just look at her, and it's all there. There's nothing … nothing else matters," he said.

De Niro was married to Diahnne Abbott, from 1976 to 1988. He shares son Raphael with Abbott, and has twin sons Aaron and Julian from a previous relationship with actress Toukie Smith.

Last month, a suspicious package containing what authorities described as a crude pipe bomb was discovered at De Niro's New York City office. But De Niro seemed unfazed, telling people, "There's something more powerful than bombs, and that's your vote. People must vote!"